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Table 1 Summary of Findings: Community-based treatment compared with traditional hospitalization for MDR-TB and XDR-TB patients

From: Community-based management versus traditional hospitalization in treatment of drug-resistant tuberculosis: a systematic review and meta-analysis

Author, Year, Country of Study, Study period Arm, N, Percent Female, Age Intervention Components Intervention setting, Intervention provider, Length of DOTS Drug model, number of drugs, treatment duration (intensive, continuation phase), Proportion previously treated
Brust JC 2012 [12] Prospective cohort South Africa 2008–2010 Community-based intervention N = 80 Female: 63 % Age: 34 HIV+: 83 % Extensive training of PHC staff, Routine home visits, Clinician support, DOTS supervised by healthcare worker, DOTS supervised by family treatment supporter, DOTS supervised by a healthcare worker, Education of patients and family treatment supporter, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers & HIV treatment Decentralized, outpatient Friends/relatives staying close by, Home care support, DOTS nurse, Community Health Extension Worker (CHEW) Throughout therapy Standardized 6, NR 6, 24 NR
Brust JC 2010 [39] Retrospective cohort South Africa 2000–2003 Traditional hospitalization N = 1209 Female: 39 % Age: 33 HIV+: 52 % Hospitalization Hospital No DOTS provider Partial Observation Standardized 5,4 4-6, 18 NR
Cox H 2007 [41] Retrospective cohort Uzbekistan 2003–2005 Traditional Hospitalization N = 87 Female: 39.1 % Age: 31 HIV+: NR Hospitalization Hospital Trained facility based healthcare worker NR Individualized 6, NR 6,18 100 %
Cox H 2014 [30] Retrospective cohort South Africa 2005–2011 Community-based intervention N = 1208 Female: 50 % Age: 33 HIV+: 70 % Extensive training of primary health care center (PHC) staff, Routine home visits, Clinician support, Social assistance and support groups, DOTSa supervised by healthcare worker PHC Trained facility based healthcare worker Throughout therapy Standardized 5, NR b 6, 18 NR
Hirpa S 2013 [42] Case control study Ethiopia 2011–2012 Traditional Hospitalization N = 134 Female: 39.5 % Age: 25.1 HIV+: 13.4 % Clinician support Healthcare workers Hospital Trained facility based healthcare worker Partial observation Standardized 5, NR NR, NR NR, NR
Joseph P 2011 [33] Prospective cohort India 2006–2007 Community-based intervention N = 38 Female: 34.2 % Age: NR HIV+: NR Extensive training of PHC center staff, Routine home visits, education of patients and family treatment supporter, Supply of drugs to local health center NR Trained facility based healthcare worker, Friends/relatives staying close by, Private medical practitioners Throughout therapy Standardized 6,4 6–9, 18 NR
Keshavjee S 2008 [38] Retrospective cohort Russia 2000–2004 Traditional Hospitalization N = 608 Female: NR Age: 33.9 HIV+: NR Hospitalization and DOTS supervised by healthcare worker Hospital DOTS supervised by healthcare worker Partial Observation Individualized 5, 5 6–9, 18 100 %
Liu CH 2011 [37] Retrospective cohort China 1996–2009 Traditional Hospitalization N = 576 Female: 33.9 % Age: 41 HIV+: NR Clinician support Hospital NR NR Individualized 5, NR c 18, 18 68.7 %
Vaghela JF 2015 [14] Prospective cohort India 2009–2012 Community-based intervention N = 101 Female: 40.6 % Age: 33 HIV+: NR Extensive training of primary health care center staff, Physical and mental support Counseling, Routine home visits, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers, Vocational rehabilitation, Hygiene & Nutrition counseling, Nursing care, Financial rehabilitation PHC, Patient home Trained facility based healthcare worker, Home care support Throughout therapy NR NR, NR 6, 24–27 NR
Oyieng’o D 2012 [11] Retrospective cohort Kenya 2008–2010 Community-based intervention N = 14 Female: 50 % Age: NR HIV+: 50 % Extensive training of PHC staff, Routine home visits, Clinician support, DOTS supervised by family treatment supporter, DOTS supervised by healthcare worker, Education of patients and family treatment supporter, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers Decentralized, Local Health Centre Friends/relatives staying close by, Home care support, DOTS nurse, CHEW Throughout therapy Standardized 5,4 6, 18 NR
Singla R 2009 [34] Retrospective cohort India 2002–2006 Community-based intervention N = 126 Female: 42 % Age: 26 HIV+: NR DOTS supervised by family treatment supporter, Daily supervised treatment in peripheral health centers, decentralized care Decentralized Friends and family staying close by Throughout therapy Standardized 5,3 6–9, 18 NR
Shin SS 2007 [40] Retrospective cohort Russia 2000–2002 Traditional Hospitalization N = 244 Female: 9.2 % Age: 31 HIV+: NR Hospitalization and trained facility based healthcare worker Trained facility based healthcare worker Throughout therapy Individualized NR, NR 18.5, 18 100 %
Tupasi TE 2006 [31] Retrospective cohort Philippines 1999–2002 Community-based intervention N = 117 Female: 26 % Age: 38 HIV+: NR DOTS supervised by healthcare worker, Daily supervised treatment in peripheral health centers, Home based DOTS PHC, Patient home Trained facility based healthcare worker Partial Observation Individualized NR, NR 6, 18 18.8 %
Thomas A 2007 [32] Prospective cohort India 1999–2003 Community-based intervention N = 66 Female: 30.3 % Age: 38 HIV+: NR Routine home visits, Clinician support, DOTS supervised by healthcare worker, Financial rehabilitation PHC, Patient home Trained facility based healthcare worker, Village health worker, private provider Partial Observation Individualized 5,NR 6–9, 12 100 %
Van Deun A 2010 [36] Prospective cohort Bangladesh 1997–2007 Traditional hospitalization N = 427 Female: 25.5 % Age: 31.7 HIV+: NR Clinician support Hospital Trained facility based healthcare worker NR Standardized NR, NR NR, NR 100 %
Wei X 2015 [35] Retrospective cohort Ethiopia 2990–2102 Community- based intervention N: 110 Female: 26.4 % HIV+: Yes (NR) Routine home visits, DOTS supervised by healthcare worker and family PHC, Patient home Village health worker, family Throughout therapy Standardized 5, NR 6, 18 NR
  1. aDOTS, Directly observed therapy short course
  2. b NR Not reported
  3. c NR Not reported