Author, Year, Country of Study, Study period | Arm, N, Percent Female, Age | Intervention Components | Intervention setting, Intervention provider, Length of DOTS | Drug model, number of drugs, treatment duration (intensive, continuation phase), Proportion previously treated |
---|---|---|---|---|
Brust JC 2012 [12] Prospective cohort South Africa 2008–2010 | Community-based intervention N = 80 Female: 63 % Age: 34 HIV+: 83 % | Extensive training of PHC staff, Routine home visits, Clinician support, DOTS supervised by healthcare worker, DOTS supervised by family treatment supporter, DOTS supervised by a healthcare worker, Education of patients and family treatment supporter, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers & HIV treatment | Decentralized, outpatient Friends/relatives staying close by, Home care support, DOTS nurse, Community Health Extension Worker (CHEW) Throughout therapy | Standardized 6, NR 6, 24 NR |
Brust JC 2010 [39] Retrospective cohort South Africa 2000–2003 | Traditional hospitalization N = 1209 Female: 39 % Age: 33 HIV+: 52 % | Hospitalization | Hospital No DOTS provider Partial Observation | Standardized 5,4 4-6, 18 NR |
Cox H 2007 [41] Retrospective cohort Uzbekistan 2003–2005 | Traditional Hospitalization N = 87 Female: 39.1 % Age: 31 HIV+: NR | Hospitalization | Hospital Trained facility based healthcare worker NR | Individualized 6, NR 6,18 100 % |
Cox H 2014 [30] Retrospective cohort South Africa 2005–2011 | Community-based intervention N = 1208 Female: 50 % Age: 33 HIV+: 70 % | Extensive training of primary health care center (PHC) staff, Routine home visits, Clinician support, Social assistance and support groups, DOTSa supervised by healthcare worker | PHC Trained facility based healthcare worker Throughout therapy | Standardized 5, NR b 6, 18 NR |
Hirpa S 2013 [42] Case control study Ethiopia 2011–2012 | Traditional Hospitalization N = 134 Female: 39.5 % Age: 25.1 HIV+: 13.4 % | Clinician support Healthcare workers | Hospital Trained facility based healthcare worker Partial observation | Standardized 5, NR NR, NR NR, NR |
Joseph P 2011 [33] Prospective cohort India 2006–2007 | Community-based intervention N = 38 Female: 34.2 % Age: NR HIV+: NR | Extensive training of PHC center staff, Routine home visits, education of patients and family treatment supporter, Supply of drugs to local health center | NR Trained facility based healthcare worker, Friends/relatives staying close by, Private medical practitioners Throughout therapy | Standardized 6,4 6–9, 18 NR |
Keshavjee S 2008 [38] Retrospective cohort Russia 2000–2004 | Traditional Hospitalization N = 608 Female: NR Age: 33.9 HIV+: NR | Hospitalization and DOTS supervised by healthcare worker | Hospital DOTS supervised by healthcare worker Partial Observation | Individualized 5, 5 6–9, 18 100 % |
Liu CH 2011 [37] Retrospective cohort China 1996–2009 | Traditional Hospitalization N = 576 Female: 33.9 % Age: 41 HIV+: NR | Clinician support | Hospital NR NR | Individualized 5, NR c 18, 18 68.7 % |
Vaghela JF 2015 [14] Prospective cohort India 2009–2012 | Community-based intervention N = 101 Female: 40.6 % Age: 33 HIV+: NR | Extensive training of primary health care center staff, Physical and mental support Counseling, Routine home visits, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers, Vocational rehabilitation, Hygiene & Nutrition counseling, Nursing care, Financial rehabilitation | PHC, Patient home Trained facility based healthcare worker, Home care support Throughout therapy | NR NR, NR 6, 24–27 NR |
Oyieng’o D 2012 [11] Retrospective cohort Kenya 2008–2010 | Community-based intervention N = 14 Female: 50 % Age: NR HIV+: 50 % | Extensive training of PHC staff, Routine home visits, Clinician support, DOTS supervised by family treatment supporter, DOTS supervised by healthcare worker, Education of patients and family treatment supporter, Adherence support and adverse event monitoring, Mobile multidisciplinary teams of home care providers | Decentralized, Local Health Centre Friends/relatives staying close by, Home care support, DOTS nurse, CHEW Throughout therapy | Standardized 5,4 6, 18 NR |
Singla R 2009 [34] Retrospective cohort India 2002–2006 | Community-based intervention N = 126 Female: 42 % Age: 26 HIV+: NR | DOTS supervised by family treatment supporter, Daily supervised treatment in peripheral health centers, decentralized care | Decentralized Friends and family staying close by Throughout therapy | Standardized 5,3 6–9, 18 NR |
Shin SS 2007 [40] Retrospective cohort Russia 2000–2002 | Traditional Hospitalization N = 244 Female: 9.2 % Age: 31 HIV+: NR | Hospitalization and trained facility based healthcare worker | Trained facility based healthcare worker Throughout therapy | Individualized NR, NR 18.5, 18 100 % |
Tupasi TE 2006 [31] Retrospective cohort Philippines 1999–2002 | Community-based intervention N = 117 Female: 26 % Age: 38 HIV+: NR | DOTS supervised by healthcare worker, Daily supervised treatment in peripheral health centers, Home based DOTS | PHC, Patient home Trained facility based healthcare worker Partial Observation | Individualized NR, NR 6, 18 18.8 % |
Thomas A 2007 [32] Prospective cohort India 1999–2003 | Community-based intervention N = 66 Female: 30.3 % Age: 38 HIV+: NR | Routine home visits, Clinician support, DOTS supervised by healthcare worker, Financial rehabilitation | PHC, Patient home Trained facility based healthcare worker, Village health worker, private provider Partial Observation | Individualized 5,NR 6–9, 12 100 % |
Van Deun A 2010 [36] Prospective cohort Bangladesh 1997–2007 | Traditional hospitalization N = 427 Female: 25.5 % Age: 31.7 HIV+: NR | Clinician support | Hospital Trained facility based healthcare worker NR | Standardized NR, NR NR, NR 100 % |
Wei X 2015 [35] Retrospective cohort Ethiopia 2990–2102 | Community- based intervention N: 110 Female: 26.4 % HIV+: Yes (NR) | Routine home visits, DOTS supervised by healthcare worker and family | PHC, Patient home Village health worker, family Throughout therapy | Standardized 5, NR 6, 18 NR |