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Table 2 Efficiency of curative intervention under different targeting scenarios

From: The potential impact of a “curative intervention” for HIV: a modelling study

Infections averted per cure (Infections averted per person benefitting from the Curative Intervention)
  Pessimistic Neutral Optimistic
Cure available irrespective of ART status
 No prioritisation 0.54 (2768/5080) 0.57 (2143/3731) 0.18 (212/1169)
 Age and risk prioritisation 0.77 (3097/4033) 0.64 (1830/2869) 0.12 (116/930)
 Age prioritisation 1.2 (5302/4449) 1.1 (3723/3330) 0.29 (351/1228)
 Risk prioritisation 0.62 (2605/4193) 0.54 (1573/2931) 0.1 (95/912)
Cure available only for those On ART
 No prioritisation 0.22 (684/3181) 0.28 (856/3069) 0.14 (142/1046)
 Age and risk prioritisation 0.35 (1222/3444) 0.39 (1107/2813) 0.11 (86/810)
 Age prioritisation 0.39 (1467/3737) 0.54 (1803/3365) 0.24 (260/1106)
 Risk prioritisation 0.25 (824/3242) 0.29 (796/2749) 0.08 (65/787)
Cure available only for those Off ART
 No prioritisation 0.7 (2179/3125) 0.87 (1456/1666) 0.57 (100/175)
 Age and risk prioritisation 0.94 (2807/2973) 0.93 (1556/1673) 0.31 (77/251)
 Age prioritisation 1.5 (4598/3045) 1.7 (3021/1748) 0.87 (234/270)
 Risk prioritisation 0.74 (2220/3020) 0.75 (1215/1627) 0.24 (52/216)
  1. Shown in bold are the number of infections averted per person benefitting from the curative intervention (both counted only in the period 2040–2059). Infections averted are calculated as the difference between the number of infections between 2040 and 2059 in the background scenario in which a curative intervention is not introduced and the number of infections in the comparison scenario between 2040 and 2059 in which one is available. The numbers of infections averted and cures are shown in grey in parentheses. “No prioritisation” means that all age/risk groups have the same access to the curative intervention. “Age-prioritisation” means that persons aged 15–24 years have 8-times the rate of benefitting from the curative intervention as older persons aged 25+ years. “Risk prioritisation” means that only persons in the higher risk group can benefit from the curative interventions