Reflecting on tuberculosis case notification and treatment outcomes in the Volta region of Ghana: a retrospective pool analysis of a multicentre cohort from 2013 to 2017

Table 3 Logistic regression of patient and disease characteristics as predictors of unsuccessful treatment outcomes

Variable	Unsuccessful treatment n (%)	COR	95% CI	P-value	AOR	95% CI	P-value
Age group (years)				0.37
< 15	22 (14.4)	1
15–64	516 (17.9)	1.29	0.82–2.1
64+	91 (16.3)	1.16	0.69–1.91
Sex				0.33
Female	225 (16.7)	1
Male	404 (17.9)	1.09	0.91–1.31
Patient category				0.002
New	593 (17.1)	1			1
Default	14 (48.3)	4.52	2.16–9.41		3.62	1.66–7.91	0.001
Relapse	13 (25.5)	1.56	0.88–3.12		1.73	0.89–3.36	0.10
Treatment Failure	5 (22.7)	1.42	0.52–3.87		1.99	0.72–5.58	0.18
Others*	4 (20.0)	1.21	0.40–3.63		1.37	0.45–4.18	0.58
TB classification^§				0.010
EP	14 (13.1)	1			1
PP	255 (15.4)	1.21	0.68–2.16		0.96	0.54–1.74	0.90
PN	360 (19.5)	1.61	0.91–2.85		1.29	0.72–2.31	0.40
HIV status				< 0.001
Negative	347 (14.7)	1			1
Positive	180 (26.5)	2.09	1.71–2.57		1.94	1.57–2.40	< 0.001
Unknown	102 (18.2)	1.29	1.01–1.64		1.17	0.91–1.52	0.22
District of treatment				< 0.001
Central Tongu	56 (28.7)	1			1
Keta	66 (15.0)	0.44	0.29–0.66		0.49	0.28–0.67	0.001
Hohoe	67 (17.9)	0.54	0.36–0.82		0.61	0.39–0.93	0.02
Ketu South	195 (18.6)	0.55	0.39–0.77		0.51	0.36–0.74	< 0.001
Krachi West	11 (9.2)	0.25	0.13–0.51		0.29	0.15–0.59	0.001
Krachi East	23 (14.1)	0.41	0.24–0.69		0.45	0.26–0.78	0.005
Kpando	54 (14.8)	0.43	0.28–0.66		0.44	0.28–0.69	< 0.001
Nkwanta South	51 (15.2)	0.45	0.29–0.68		0.48	0.31–0.75	0.001
South Tongu	61 (29.5)	1.03	0.67–1.59		1.11	0.71–1.72	0.65
Kadjebi	45 (13.9)	0.40	0.26–0.62		0.41	0.26–0.64	< 0.001
Year of registration				0.29
2013	126 (16.9)	1
2014	119 (15.6)	0.91	0.69–1.91
2015	119 (17.0)	1.00	0.76–1.32
2016	119 (18.1)	1.08	0.82–1.43
2017	146 (19.8)	1.21	0.93–1.57

^§missing value: 2; COR Crude odds ratio; AOR Adjusted odds ratio, EP Extrapulmonary, PP Pulmonary positive, PN Pulmonary negative

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