Safety and efficiency of stem cell therapy for COVID-19: a systematic review and meta-analysis

Table 2 Numbers of AEs and patients with AEs

Article	Numbers of patients with AEs, n(%), Experimental; Ctrl	Numbers of AEs, n, experimental; Ctrl	Numbers of patients with SAEs, n(%), experimental; Ctrl	Numbers of SAEs, n, experimental; Ctrl	Number of AEs related to teatment, n
Lanzoni et al. [15]	8(66.7) ; 11(91.67)	46 ; 53	2(16.7) ; 8(66.7)	6 ; 16	1*
Ventura-Carmenate et al. [16]**	50(72.5) ; 51(72.9)	107 ; 133	NR ; NR	NR ; NR	0
Torres Zambrano et al. [17]**	NR ; NR	NR ; NR	NR ; NR	NR ; NR	NR
Shi et al. [18]***	37(56.9) ; 21(60)	72 ; 36	1(1.5) ; 0	1 ; NR	0
Shi et al. [19]***	54(83.1) ; 26(74.3)	106 ; 54	1(1.5) ; 0	1 ; NR	0
Zhu et al. [20]	3(10.3) ; 13(44.8)	20 ; 34	0 ; 0	0 ; 0	0
Adas et al. [21]	NR ; NR	NR ; NR	NR ; NR	NR ; NR	NR
Dilogo et al. [22]	0 ; NR	0 ; NR	0 ; NR	0 ; NR	0
Torres Zambrano et al. [23]**	NR ; NR	NR ; NR	NR ; NR	NR ; NR	NR
Torres Zambrano et al. [24]**	NR ; NR	NR ; NR	NR ; NR	NR ; NR	NR
Wei et al. [25]	1(8.3) ; NR	3 ; NR	1(8.3) ; NR	3 ; NR	0
Xu et al. [26]	20(76.9) ; 18(100)	56 ; 59	NR ; NR	10 ; 15	0
Meng et al. [27]	3(33.3) ; NR	4 ; NR	0 ; NR	0 ; NR	3*
Häberle et al. [28]	NR ; NR	NR ; NR	NR ; NR	NR ; NR	NR
O.Ercelen et al. [29]	NR ; NR	NR; NR	0 ; NR	0 ; NR	0
Leng et al. [30]	NR ; NR	NR ; NR	0 ; NR	0 : NR	0
Shu et al. [31]	NR ; NR	NR ; NR	NR ; NR	NR ; NR	0

AEs adverse events, SAEs serious adverse events
*The former study [15] mentioned three “infusion associated events” during the first round of infusion. The latter study [27] reported number of AEs in relationship to treatment and only one AE was considered “Probable”, which is the highest degree in reported relationship.
**These four studies are based on one clinical trial. The first study [16] focused on the safety and efficacy of stem cell therapy. The second study emphasized the radiographic outcome [17]. The third study [23] focused only on the renal involvement of the critically ill patients in the trial, and the last study [24] explored secondary sepsis and urinary tract infections in patients.
***These two studies are based on the same patients. The latter [19] is a one-year follow-up of the former and contains all AEs of the former [18].

ISSN: 2397-0642