Table 1 General characteristics of the included studies
Author (references) | Country | Publication year | Affiliation | Domain | Type of study | Model used | Intervention and comparator |
|---|---|---|---|---|---|---|---|
Adibi et al. [21] | Iran | 2004 | National | Infectious | CEA (per infection averted) | Decision tree | HBsAg screening for all premarriage individuals and prevention protocol for seronegative subjects or HBsAg screening for all premarriage individuals, HBcAb screening in the HBsAg negative spouses of the HBsAg positive persons, and prevention protocol Vs no screening and no prevention |
Al Abri et al. [22] | Oman | 2020 | National and International | Infectious | CUA (per QALY) | Decision tree and Markov | Different testing programs using an IGRA versus the TST, combined with QFT-Plus with 6H, QFT-Plus with 3HP, QFT-Plus with 4R, TST with 6H, TST with 3HP and directly observed therapy, TST with 4R, Vs CXR alone |
Al‐Qudah et al. [23] | Jordan | 2019 | National and International | NCDs | CBA | NA | Clinical pharmacist intervention (home medication management review, patient education on drug-drug interactions, dosage adjustment, patient education on the importance of adherence to their medication regime, etc.) Vs routine care |
Assanelli et al. [24] | Algeria and others | 2015 | National and International | CVDs | CEA (per LYG) | NR | ECG in combination with family and personal history and physical examination (no comparator was reported) |
Balicer et al. [25] | Israel | 2005 | National | Infectious | CBA | NA | 3 strategies for the use of stockpiled antiviral drugs during a pandemic: (1) therapeutic use, (2) long-term preexposure prophylaxis, and (3) short-term postexposure prophylaxis for close contacts of influenza patients |
Barfar et al. [26] | Iran | 2014 | National | Cancer | CEA (per case detected) | NR | Mammography breast cancer screening Vs no screening |
Carvalho et al. [27] | Afghanistan | 2013 | National and International | Maternal diseases | CEA (per LYS) | Decision tree | Family planning strategies Vs combined several interventions (Integrated reproductive health and pregnancy-related services) |
Chodick et al. [28] | Israel | 2005 | National | Infectious | CEA (per case avoided) | Decision tree and Markov | Mass Varicella zoster virus vaccination, screening followed by vaccination, vaccination of carriers and do nothing (status quo situation) |
Chodick et al. [29] | Israel | 2002 | National | Infectious | CUA (per QALY) | Decision tree and Markov | Mass Hepatitis A vaccination, screening and vaccination Vs passive immunization (status quo strategy) |
Chowers [30] | Israel | 2017 | National | Infectious | CUA (per QALY) | Decision tree and Markov | Universal prenatal HIV screening compared with the current high risk only screening policy |
Devine [31] | Afghanistan and others | 2020 | International | Infectious | CUA (per DALY) | Decision tree | Gender-based treatment according to qualitative G6PD rapid diagnostic screening Vs routine care |
El-Dahiyat [32] | Jordan | 2017 | National | All | CMA | NA | Generic medicines Vs originator brand medicines |
El-Ghitany [33] | Egypt | 2019 | National | Infectious | CEA (per test performed) | NR | EGCRISC use Vs mass screening |
Eltabbakh et al. [34] | Egypt | 2015 | National | Cancer | CUA (per QALY) | NR | HCC screening program by ultrasound and alpha-fetoprotein Vs diagnosis outside the program |
Gamaoun et al. [35] | Tunisia | 2018 | National | Cancer | CEA (per case avoided) | Decision tree | Two-dose HPV vaccine for young girls Vs screening with three time-lapse Pap smear test |
Ginsberg et al. [36] | Israel | 1998 | National | Genetic disorders | CBA | NA | Combined educational and national prenatal screening programs for thalassemia by blood samples test then electrophoresis for samples with abnormal values followed by counselling Vs no screening |
Ginsberg et al. [37] | Israel | 2013 | National | Cancer | CUA (per DALY) | Markov | Screening with removal of cancerous lesions, Three doses of HPV vaccine with or without booster dose every 20 years for 12-year old girls, treatment of all cancer cases, and combinations of these interventions in different scenarios Vs current policy (Treat all cases and annual screening of 12.1% of females aged 12–70 with Pap smear) |
Ginsberg et al. [38] | Israel | 2020 | National | Infectious | CUA (per DALY) | Decision tree | Continuous HIV pre-exposure prophylaxis regimen Vs on-demand HIV pre-exposure prophylaxis |
Ginsberg et al. [39] | Israel | 2007 | National | Infectious | CUA (per QALY) | Markov | Screening with Pap smear (annually, tri-annually and penta-annually), HPV-DNA testing, or Visual inspection with acetic acid (VIA) -All followed by removal of cancerous lesions-, prevention by vaccination (3 doses of HPV vaccine with or without booster dose every 10 years for 12-year old girls), treatment of all cancer cases, screening and treatment, vaccination and treatment, and combination of prevention, screening and treatment. All strategies Vs current policy (all cases are treated and 12.2% of females aged 12–70 receive Pap smear) |
Ginsberg et al. [40] | Israel | 2012 | National | CVDs | CUA (per DALY) | NR | Home, school, workplace, restaurant and supermarket-based interventions, screening, media strategies, taxation of unhealthful food products, provision of government subsidies to reduce the price of healthful foods [and vice-versa], mandatory food labeling, and prohibiting the sale of unhealthful foods in vending machines |
Haghighat et al. [41] | Iran | 2016 | National and International | Cancer | CUA (per QALY) | Decision tree and Markov | Mammography screening strategy Vs no screening |
Hamdani et al. [42] | Pakistan | 2020 | National and International | Mental diseases | CEA (per unit change in anxiety, depression and functioning scores) | NR | Problem Management + Vs enhanced usual care |
Howard et al. [43] | Pakistan | 2017 | National and International | Infectious | CUA (per DALY), CEA (per LYG, case prevented, death prevented) | NR | Vector control using annual indoor residual spraying Vs routine malaria diagnosis and treatment |
Hussain et al. [44] | Pakistan | 2019 | International | Infectious | CUA (per DALY), CEA (per patient treated) | Decision tree and Markov | Active case finding program using incentives Vs the existing passive case finding and treatment program |
Javadinasab et al. [45] | Iran | 2017 | National | Cancer | CUA (per QALY) and CEA (per LYG) | Markov | Colonoscopy screening every 5 years starting at age 40, screening every 10 years starting at age 40, screening every 5 years starting at age 50, screening every 10 years starting at age 50, screening once/lifetime at age 50, and screening once/lifetime at age 55 Vs no screening |
Javanbakht [46] | Iran | 2018 | National and International | CVDs | CEA (per capita healthcare cost) | Markov | Adequate dairy foods consumption Vs inadequate dairy foods consumption |
Kashi et al. [47] | Pakistan and others | 2019 | International | Malnutrition | CUA (per DALY) | Decision tree | Multiple micronutrient supplementation Vs iron and folic acid supplementation |
Khneisser et al. [48] | Lebanon | 2015 | National | Genetic disorders | CBA | NA | Expanded newborn screening for inborn errors of metabolism by using tandem mass spectrometry followed by diagnostic confirmation and management Vs clinical "late" detection |
Khneisser et al. [49] | Lebanon | 2007 | National | Genetic disorders | CBA | NA | G6PD deficiency screening Vs no screening |
Kim et al. [50] | Egypt | 2015 | National and International | Infectious | CUA (per QALY) | Decision tree and Markov | One-time screening and follow-up treatment for HCV infection Vs the current strategy of no screening |
Kim et al. [51] | Algeria, Lebanon, and Turkey | 2013 | National and International | Cancer | For vaccination: CUA (per DALY). For screening: CEA (per LYS) | Decision tree | Three doses of HPV vaccine for all 12-year girls in MENA countries and combination of screening and vaccination in Algeria, Lebanon, and Turkey Vs no intervention |
Koren et al. [52] | Israel | 2014 | National | Genetic disorders | CEA (per case prevented) | NR | Thalassemia prevention program Vs routine treatment of β Thalassemia major and its complications |
Lahiri et al. [53] | MENA and others | 2005 | International | Back pain | CEA (per LYG) | Markov | Worker training, engineering controls coupled with administrative controls, a combination of worker training and engineering controls, and the full ergonomics program Vs no intervention |
Leshno et al. [54] | Israel | 2003 | National | Cancer | CEA | Markov | One-time colonoscopic screening, colonoscopy followed by a 10-year follow-up, annual FOBT, annual FOBT and flexible sigmoidoscopy, and annual detection of altered human DNA in stool Vs no screening |
Lim et al. [55] | Pakistan | 2020 | National and international | Infectious | CEA (per cured case) | Markov | HCV Screening and treatment Vs no interventions |
Lohse et al. [56] | Israel and others | 2011 | International | DM | CUA (per DALY) | Decision tree | Gestational diabetes mellitus screening and lifestyle change Vs no intervention |
Madae’en et al. [57] | Jordan | 2020 | National | Smoking | CEA (per LYG) | Markov | Varenicline for 3 months, NRT (combined patch and gum) for 3 months, and physician advice over three visits with no medications Vs no intervention |
Marseille et al. [58] | Israel and others | 2013 | National and international | DM | CUA (per DALY) | Decision tree | Initial screening tests, antenatal care for Gestational DM women, and post-partum DM prevention interventions Vs no Gestational DM screening and treatment |
Mason et al. [59] | Tunisia, Syria, Palestine and Turkey | 2014 | National and International | CVDs | CEA (per LYG) | Decision tree | Health promotion campaign, labelling of food packaging or mandatory salt reduction of processed foods Vs no policy |
Messoudi et al. [60] | Morocco | 2019 | National and International | Cancer | CEA (per LYG) | Markov | Screening of women aged 30–49 years with a VIA test every 3 years Vs no intervention, two doses of HPV vaccine for pre-adolescent girls Vs no intervention, and combined HPV vaccine and screening Vs screening alone |
Mostafa et al. [61] | Egypt | 2019 | National and International | Infectious | CUA (per QALY) | Decision tree and Markov | Safety-engineered syringes Vs conventional syringes |
Mostafa et al. [62] | Egypt | 2019 | National | Infectious | CUA (per QALY) | Decision tree | Safety-engineered syringes Vs conventional syringes |
Nahvijou et al. [63] | Iran | 2016 | National and International | Cancer | CUA (per QALY) | Markov | 11 different screening strategies with different periodicities and different intervals Vs no screening |
Okem et al. [64] | Turkey | 2017 | National | Genetic disorders | CEA (per cases detected or procedural related losses avoided) | Decision tree | For women < 35-year of age: triple test, combined test, Non-invasive Prenatal Screening Test (NIPT) by using cell free fetal DNA, NIPT as a second-step screening for high-risk patients detected by triple test, and NIPT as a second-step screening for high-risk patients detected by combined test. For women ≥ 35-year of age: implementing invasive test (amniocentesis) and NIPT for all women were compared Vs current screening strategies |
Ornoy et al. [65] | Israel | 2019 | National | Genetic disorders | CBA | NA | National screening program for attention deficit hyperactivity disorder among school children and continue treatment until adulthood. The comparator was not reported |
Ranson et al. [66] | MENA | 2002 | International | Smoking | CUA (per DALYs) | NR | Price increases, NRT, and a package of non-price interventions other than NRT (such as comprehensive bans on advertising and promotion, bans on smoking in public places, prominent warning labels and mass consumer information). The comparator was not reported |
Rashidian et al. [67] | Iran | 2015 | National | Infectious | CEA (per percentages of volume reduction and weight reduction) | Decision tree | Medical waste treatment devices called Saray 1, Saray 2, Sazgar, KAZU, Newster, Ecodas T150, Ecodas T300, and Newster 10, Vs Caspian-Alborz |
Rezaei-Hemami et al. [68] | Iran | 2014 | National | Infectious | CEA (per averted malaria case) | NR | Larviciding, indoor residual spraying, insecticide treated net, set up the diagnosis and treatment in less than 24 h, and set up the border facilities Vs each other |
Saygili et al. [69] | Turkey | 2019 | National | Cancer | CEA (per quality of life unit and level of satisfaction) | NR | Comprehensive palliative care center, hospital inpatient services, and home healthcare services Vs each other |
Shamshiri et al. [70] | Iran | 2012 | National and International | Genetic disorders | CUA (per DALY) | Decision tree | Congenital hypothyroidism screening programs Vs no screening |
Sharma et al. [71] | Lebanon | 2017 | National and International | Cancer | CEA (per LYS) | Markov | Increasing cytologic screening coverage to 50% at 3 and 5 years interval Vs annual screening at 20% coverage |
Shlomai et al. [72] | Israel | 2020 | National | Infectious | CUA (per QALY) and CEA (per death prevented) | Markov | Social distancing and national lockdown Vs complete isolation of infected individuals or individuals at high exposure risk in a dedicated facility |
Shmueli et al. [73] | Israel | 2013 | National and International | Cancer | CUA (per QALY) | Decision tree | Low-dose computed tomography screening Vs no screening |
Sladkevicius et al. [74] | Libya | 2010 | National and International | Genetic disorders | CEA (per LYG) | Decision tree | Neonatal screening for Phenylketonuria Vs no screening |
Verguet et al. [75] | Djibouti, Mauritania, Somalia, Sudan and others | 2013 | International | Infectious | CUA (per DALY) | Markov | Adding HIV pre-exposure prophylaxis at pre-existing levels Vs existing HIV prevention interventions (male circumcision, antiretroviral therapy and condom use) |
Vijayaraghavan et al. [76] | Afghanistan | 2006 | International | Infectious | CEA (per deaths averted) | Markov | Catch-up and follow-up measles campaigns Vs no measles campaigns |
Vijayaraghavan et al. [77] | Somalia | 2012 | International | Maternal diseases | CEA (per LYG) | NR | Child health days strategy to deliver multiple maternal and child health interventions Vs ‘‘best buys’’ interventions |
Wilcox et al. [78] | Syria | 2015 | National and International | CVDs | CEA (per LYG) | Decision tree | Health promotion campaign about salt reduction, labeling of salt content on packaged foods, reformulation of salt content within packaged foods, and combinations of the three strategies Vs absence of any policy |
Yarahmadi et al. [79] | Iran | 2010 | National | Genetic disorders | CBA | NA | Newborn screening program for congenital hypothyroidism Vs no screening |
Yosefy et al. [80] | Israel | 2007 | National | CVDs | CUA (per DALY) | NR | Nationwide program to reduce hypertension Vs no intervention |
Yosefy et al. [81] | Israel | 2003 | National | CVDs | CUA (per QALY) | NR | Expansion of the blood pressure control program to 100 clinics nationwide Vs 30 clinics only |