Assessing the impact of comorbid type 2 diabetes mellitus on the disease burden of chronic hepatitis B virus infection and its complications in China from 2006 to 2030: a modeling study

Table 2 Estimated excess incident cases of severe HBV complications caused by comorbid T2DM among the HBV-infected population

HBV complications	2006–2022 (thousands)				2023–2030 (thousands)
HBV complications	HBV-model	HBV-T2DM model	Absolute difference	Relative difference (%)	HBV-model	HBV-T2DM model	Absolute difference	Relative difference (%)
Total population
Compensated cirrhosis	6932	7723	791	11.41	3456	3884	428	12.38
Decompensated cirrhosis	2632	2876	244	9.27	1243	1339	96	7.72
HCC	4293	4670	377	8.78	2415	2509	94	3.89
Total severe HBV complications	13,857	15,269	1412	10.19	7114	7732	618	8.69
Liver-related death	6529	7325	796	12.19	4035	4396	361	8.95
Adults aged 60 years and older at baseline
Compensated cirrhosis	562	705	143	25.44	180	223	43	23.89
Decompensated cirrhosis	262	305	43	16.41	91	108	17	18.68
HCC	449	539	90	20.04	148	175	27	18.24
Total severe HBV complications	1273	1549	276	21.68	419	506	87	20.76
Liver-related death	683	879	196	28.70	284	336	52	18.31
Adults between the ages of 45 and 59 at baseline
Compensated cirrhosis	1045	1236	191	18.28	392	444	52	13.27
Decompensated cirrhosis	485	564	79	16.29	165	181	16	9.70
HCC	896	976	80	8.93	296	331	35	11.82
Total severe HBV complications	2426	2776	350	14.43	853	956	103	12.08
Liver-related death	1344	1548	204	15.18	599	707	108	18.03

T2DM Type 2 diabetes mellitus, HBV Hepatitis B virus, HCC Hepatocellular carcinoma

ISSN: 2397-0642